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Respondents from China gave the highest proportion of positive responses (631 of 712 respondants, 88.6%) and the lowest proportion of negative responses (5 of 712, 0.7%) when asked if they would take a ‘proven, safe and effective vaccine’. We present findings from a survey of the likelihood of vaccine acceptance from a sample of 13,426 respondents in 19 countries. Governments and societies must gauge current levels of willingness to receive a potentially safe and effective COVID-19 vaccine and identify correlates of vaccine hesitancy and/or acceptance. The accelerated pace of vaccine development has further heightened public anxieties and could compromise acceptance 9. Misinformation spread through multiple channels could have a considerable effect on the acceptance of a COVID-19 vaccine 8. Anti-vaccination activists are already campaigning in multiple countries against the need for a vaccine, with some denying the existence of COVID-19 altogether 7. Governments, public health officials and advocacy groups must be prepared to address hesitancy and build vaccine literacy so that the public will accept immunization when appropriate.
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In many countries, vaccine hesitancy and misinformation present substantial obstacles to achieving coverage and community immunity 5, 6. Concern about vaccine hesitancy is growing worldwide 4 in fact, WHO identified it as one of the top ten global health threats in 2019 ( ). In 2015, the World Health Organization (WHO) Strategic Advisory Group of Experts on Immunization defined vaccine hesitancy as a ’delay in acceptance or refusal of vaccination despite availability of vaccination services’ 1, which can vary in form and intensity based on when and where it occurs and what vaccine is involved, as has been confirmed in multiple studies 2, 3. This will require sufficient health system capacity, as well as strategies to enhance trust in and acceptance of the vaccine and those who deliver it. Governments must be ready to ensure large-scale, equitable access and distribution of a COVID-19 vaccine if and when a safe and effective one becomes available. The COVID-19 pandemic is expected to continue to impose enormous burdens of morbidity and mortality while severely disrupting societies and economies worldwide.